Oxidative decarboxylation
Oxidative decarboxylation is a process in which carbon dioxide is produced through the removal of a carbon group as a result of oxidation reactions[1]. There are vital in many biological processes such as the citric acid cycle.
In the citric acid cycle it is used three times to generate CO2 whilst also reducing NAD+ to NADH. Firstly, pyruvate is converted by a pyruvate dehydrogenase complex to Acetyl CoA[2]. Secondly, using the enzyme Isocitrate dehydrogenase to α-Ketoglutarate[3] and finally α-Ketoglutarate dehydrogenase is used to convert α-Ketoglutarate to Succinyl CoA[4].
References
- ↑ Voet, Donald; Voet, Judith; Pratt, Charlotte (2013). Fundamentals of Biochemistry (4 ed.). John Wiley and Sons.
- ↑ Berg J.M, Tymoczko J.L, Stryer, L (2007). Biochemistry. 6th ed. New York: W. H. Freeman and Company. p477
- ↑ Berg J.M, Tymoczko J.L, Stryer, L (2007). Biochemistry. 6th ed. New York: W. H. Freeman and Company.
- ↑ Berg J.M, Tymoczko J.L, Stryer, L (2007). Biochemistry. 6th ed. New York: W. H. Freeman and Company. p485